| Pair Name | Licochalcone A, Fluorouracil | ||
| Phytochemical Name | Licochalcone A (PubChem CID: 5318998 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
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| Structure of Anticancer Drug |
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| Pair Name | Licochalcone A, Fluorouracil | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | IFI27 | hsa3429 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | SGC-7901 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0520 |
| MKN45 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0434 | |
| Result | LCA alone or in combination with 5-FU may have significant anticancer effects on gastric cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells. Oncol Lett. 2017 Mar;13(3):1695-1701. doi: 10.3892/ol.2017.5614. | Click |
